Methanol → 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine

HRID 1371504노트

반응식

HRID 1371504 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[N+:22]([O-])=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO>C1COCC1.[Pt]>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[NH2:22])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 212627651-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine

생성물 1

HCID 211930651-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine수율 99.1%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8028Tetrahydrofuran용매

실험 절차

10.1 g 1-Benzyl-4-(4-fluoro-2-nitro-phenylamino)-piperidine were dissolved in 75 ml THF and 75 ml methanol and hydrogenated with 1.5 g Pt/C (10%). The catalyst was filtered, and the filtrate was evaporated to yield 9.1 g of the target compound as an oil.

후처리

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-75336fe606ce4ac4a808dac1ce0bf69d
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157471B2

반응 노트

불러오는 중…