2-methylthio-5-trifluoromethyl-1H-indole → 5-(trifluoromethyl)-1H-indole
반응식
CS[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][CH:6]=2>[Ni].C(O)C>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][CH:3]=[CH:11]2참가 물질
4
실험 절차
Combine moist Raney nickel (330 g), 2-methylthio-5-trifluoromethyl-1H-indole (33.8 g, 146.2 mmol) and absolute ethanol (850 ml) and stir. After 1.5 hours, filter the mixture through celite and wash the celite with ethanol (500 ml). Evaporate the filtrate to dryness, add toluene (20 ml) and evaporate and dry to give 5-trifluoromethylindole: mp=55–60° C.
후처리
- filtrationfilter the mixture through celite
- washwash the celite with ethanol (500 ml)
- customEvaporate the filtrate to dryness
- additionadd toluene (20 ml)
- customevaporate
- customdry
출처 및 근거
- ORD 기록
- ord-de4e169c35db4b5d968949cc7017f7e7
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157488B2
반응 노트
불러오는 중…