Hydrochloric Acid → 870562-26-8
반응식
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([F:13])=[CH:5][CH:4]=1)#[N:2].[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1참가 물질
5
실험 절차
A solution of 1-cyano-4-fluoronapthalene (1.05 g, 6.12 mmol) and 1.5 mL of HCl (aq.) in absolute ethanol (50 mL) was stirred under a hydrogen atmosphere (balloon) with 10% palladium on carbon (0.20 g) for 16 hours. The catalyst was removed by filtration through Celite, and the filtrate concentrated under vacuum. The resulting solid was triturated with ether and collected by filtration to give the title compound (0.575 g, 44% yield) as an off white solid.
후처리
- customThe catalyst was removed by filtration through Celite
- concentrationthe filtrate concentrated under vacuum
- customThe resulting solid was triturated with ether
- filtrationcollected by filtration
출처 및 근거
- ORD 기록
- ord-86df18034fe44a3c8752a294beb48a19
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157447B2
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