Hydrochloric Acid → 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride

HRID 1372254

반응식

HRID 1372254 반응식
[F:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:11]>[Pd].C(O)C.O1CCCC1>[ClH:11].[F:1][C:2]1[C:3]([CH2:9][NH2:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 27832532-Cyano-3,5-difluoropyridine

생성물 1

HCID 210698531-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

A mixture of 3,5-difluoropicolinonitrile (1.4 g, 10 mmol), conc.HCl (12 ml) and 10% Pd—C (200 mg) in 1:1 ethanol/tetrahydrofuran was shaken under a hydrogen atmosphere (50 psi) for 5 h. The reaction mixture was filtered and the ethanol removed in vacuo. The remaining solution was lyophilized to afford an off-white solid (2.16 g, 100% yield). LCMS (M+H) calcd for C6H7F2N2: 145.06. found: 145.12.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe ethanol removed in vacuo

출처 및 근거

ORD 기록
ord-5a4e999dfdc745588a16416be98a9c54
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157447B2

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