Hydrochloric Acid → Ethyl 3-Iodobenzimidate hydrochloride

반응식

[ClH:1].[I:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7].[CH2:11]([OH:13])[CH3:12]>>[ClH:1].[I:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6](=[NH:7])[O:13][CH2:11][CH3:12]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 1443413-Iodobenzonitrile

생성물 1

HCID 21071767Ethyl 3-Iodobenzimidate hydrochloride

실험 절차

Hydrogen chloride gas was bubbled into a solution of 3-iodobenzonitrile (2.00 g, 8.73 mmol) in 20 mL of absolute ethanol for 30 min at room temperature. The resultant solution was kept at room temperature for 48 h, and was then concentrated under reduced pressure. The residue was triturated with diethyl ether, collected and dried in vacuo to afford the product as a white powder.