Sodium Hydroxide → (2-(4-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid

HRID 1372647노트

반응식

HRID 1372647 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[O:10][C:11]3[C:17]([F:18])=[C:16]([CH2:19][C:20]([O:22]C)=[O:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([CH3:24])[CH:3]=1.[OH-].[Na+]>C1COCC1.CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[O:10][C:11]3[C:17]([F:18])=[C:16]([CH2:19][C:20]([OH:22])=[O:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([CH3:24])[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778975Methyl (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetate

생성물 1

HCID 17859146(2-(4-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid수율 109.2%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

In THF/methanol (2:1, v/v, 120 ml) was dissolved methyl (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetate (1.32 g, 3.97 mmol). To the resulting solution was added 1N NaOH (40 ml). After stirring at room temperature for 12 hours, the reaction mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid (1.38 g, 100%) as a colorless solid.

후처리

  1. distillationthe reaction mixture was distilled under reduced pressure
  2. customto remove the solvent
  3. customThe crystals thus precipitated
  4. filtrationwere collected by filtration under reduced pressure
  5. washwashed with water
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-de0275cc87394541807685925831e4da
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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