Sodium Hydroxide → (4-(2-Benzoxazolyl)amino-5-chloro-2-fluorophenyl)acetic acid

HRID 1372669

반응식

HRID 1372669 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]1[C:16]([Cl:17])=[CH:15][C:14]([CH2:18][C:19]([O:21]CC)=[O:20])=[C:13]([F:24])[CH:12]=1.[OH-].[Na+]>C1COCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]1[C:16]([Cl:17])=[CH:15][C:14]([CH2:18][C:19]([OH:21])=[O:20])=[C:13]([F:24])[CH:12]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778947Ethyl (4-(2-benzoxazolyl)amino-5-chloro-2-fluorophenyl)acetate

생성물 1

HCID 17858898(4-(2-Benzoxazolyl)amino-5-chloro-2-fluorophenyl)acetic acid수율 95.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl (4-(2-benzoxazolyl)amino-5-chloro-2-fluorophenyl)acetate (570 mg, 1.63 mmol) was dissolved in THF (5 ml). To the resulting solution was added 1N NaOH (5.0 ml, 5.00 mmol), followed by stirring at room temperature for 20 hours. The reaction mixture was poured in ice-1N HCl to acidify therewith. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(2-benzoxazolyl)amino-5-chloro-2-fluorophenyl)acetic acid (497 mg, 95%) as a brown solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-8fe22556ae8f47298512c65b54a86b66
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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