Sodium Hydroxide → HCID 17859065, 화합물

HRID 1372671노트

반응식

HRID 1372671 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]C)=[O:19])=[CH:13][C:12]=1[Cl:22].[OH-].[Na+]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:13][C:12]=1[Cl:22]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778646HCID 58778646, 화합물

생성물 1

HCID 17859065HCID 17859065, 화합물수율 93%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In THF (5 ml) was dissolved methyl (4-(2-benzothiazolyl)amino-3-chlorophenyl)acetate (296 mg, 0.89 mmol). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCl to acidify the mixture. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(2-benzothiazolyl)amino-3-chlorophenyl)acetic acid (263 mg, 93%) as a white solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-658097d0357f42d5a1c5f869d74d0414
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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