Sodium Hydroxide → (3-Chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid

HRID 1372675

반응식

HRID 1372675 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([O:22]C)=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:12]=2[N:13]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:19][C:20]([OH:22])=[O:21])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:12]=2[N:13]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778443Methyl (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetate

생성물 1

HCID 17858843(3-Chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid수율 77%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetate (274 mg, 0.79 mmol) was dissolved in THF (5 ml). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol), followed by stirring at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCR. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-(6-methyl-2-benzothiazolyl)aminophenyl)acetic acid (202 mg, 77%) as a pale yellow solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-53a24afdd19748c783a8fbeaf88056cd
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

연결된 노트

불러오는 중…