Sodium Hydroxide → (4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid

HRID 1372677

반응식

HRID 1372677 반응식
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778710Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate

생성물 1

HCID 17859264(4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid수율 95%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate (271 mg, 0.74 mmol) was dissolved in THF (4.5 ml). To the resulting solution was added 0.5N NaOH (4.5 ml, 2.25 mmol), followed by stirring at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid (248 mg, 95%) as a pale yellow solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-58fdca4463604b758be4983dfb04ed57
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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