Sodium Hydroxide → (5-Chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid

HRID 1372684

반응식

HRID 1372684 반응식
[Cl:1][C:2]1[C:3]([NH:15][C:16]2[S:17][C:18]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:19]=3[N:20]=2)=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:3]([NH:15][C:16]2[S:17][C:18]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:19]=3[N:20]=2)=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58778765Ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate

생성물 1

HCID 17859016(5-Chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid수율 86%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetate (298 mg, 0.78 mmol) was dissolved in THF (5 ml). To the resulting solution was added 0.5N NaOH (5.0 ml, 2.50 mmol). The resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (5-chloro-4-(5-fluoro-2-benzothiazolyl)amino-2-fluorophenyl)acetic acid (237 mg, 86%) as a pale yellow solid.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-6eed12fa04614de5ba0408d49f072efe
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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