Sodium Hydroxide → HCID 17859077, 화합물

HRID 1372694노트

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HRID 1372694 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:25][C:26]([O:28]C)=[O:27])[CH:7]=[CH:8][C:9]=1[NH:10][C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]([CH:22]([CH3:24])[CH3:23])[CH:14]=1)=[O:12]>C1COCC1>[Cl:3][C:4]1[CH:5]=[C:6]([CH2:25][C:26]([OH:28])=[O:27])[CH:7]=[CH:8][C:9]=1[NH:10][C:11]([C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]([CH:22]([CH3:23])[CH3:24])[CH:14]=1)=[O:12]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 17859043HCID 17859043, 화합물

생성물 1

HCID 17859077HCID 17859077, 화합물수율 93%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
50 °C

실험 절차

In THF (6.0 ml) was dissolved the methyl 3-chloro-4-((1-isopropyl-3-indolylcarbonyl)amino)phenylacetate obtained in the above-described (Step 3). To the resulting solution was added 0.25N NaOH (6.0 ml), followed by stirring at 50° C. for 18 hours. After cooling, the reaction mixture was distilled under reduced pressure to remove the solvent. The resulting residue was acidified with 1N HCl (2.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 3-chloro-4-((1-isopropyl-3-indolylcarbonyl)amino)phenylacetic acid (246.2 mg, 93%) as a brown amorphous substance.

후처리

  1. customobtained in the above-described (Step 3)
  2. temperatureAfter cooling
  3. distillationthe reaction mixture was distilled under reduced pressure
  4. customto remove the solvent
  5. customThe crystals thus precipitated
  6. filtrationwere collected by filtration under reduced pressure
  7. washwashed with water
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ad7c951aa88d4cba8570d2040ffc3a33
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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