Sodium Hydroxide → 2-Methyl-2H-indazole-3-carboxylic acid

HRID 1372741

반응식

HRID 1372741 반응식
[CH3:1][N:2]1[C:10]([C:11]([O:13]C)=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1.[OH-].[Na+]>C1COCC1>[CH3:1][N:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11658425Methyl 2-methyl-2H-indazole-3-carboxylate

생성물 1

HCID 70605372-Methyl-2H-indazole-3-carboxylic acid수율 91%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To methyl 2-methylindazole-3-carboxylate (1.59 g, 8.36 mmol) were added THF (85 ml) and 0.25N NaOH (50 ml, 12.5 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. To the residue was added water, followed by the addition of 1N HCl (50 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methylindazole-3-carboxylic acid (1.34 g, 91%) as a colorless solid.

후처리

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customto remove the solvent
  3. additionTo the residue was added water
  4. additionfollowed by the addition of 1N HCl (50 ml)
  5. customThe crystals thus precipitated
  6. filtrationwere collected by filtration under reduced pressure
  7. washwashed with water
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-a49fee857c3c4b2b856781d27004a7ab
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07157487B2

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