Sodium Hydroxide → 2-Methyl-2H-indazole-3-carboxylic acid
반응식
[CH3:1][N:2]1[C:10]([C:11]([O:13]C)=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1.[OH-].[Na+]>C1COCC1>[CH3:1][N:2]1[C:10]([C:11]([OH:13])=[O:12])=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8]2)=[N:3]1참가 물질
4
실험 절차
To methyl 2-methylindazole-3-carboxylate (1.59 g, 8.36 mmol) were added THF (85 ml) and 0.25N NaOH (50 ml, 12.5 mmol) and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. To the residue was added water, followed by the addition of 1N HCl (50 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methylindazole-3-carboxylic acid (1.34 g, 91%) as a colorless solid.
후처리
- distillationThe reaction mixture was distilled under reduced pressure
- customto remove the solvent
- additionTo the residue was added water
- additionfollowed by the addition of 1N HCl (50 ml)
- customThe crystals thus precipitated
- filtrationwere collected by filtration under reduced pressure
- washwashed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-a49fee857c3c4b2b856781d27004a7ab
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07157487B2
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