Sodium Hydroxide → HCID 17859101, 화합물
반응식
[F:1][C:2]1[C:10]2[O:9][C:8]([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH:14]=[CH:13][N:12]=3)=[N:7][C:6]=2[CH:5]=[CH:4][C:3]=1[CH2:21][C:22]([O:24]C)=[O:23].[OH-].[Na+]>C1COCC1>[F:1][C:2]1[C:10]2[O:9][C:8]([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH:14]=[CH:13][N:12]=3)=[N:7][C:6]=2[CH:5]=[CH:4][C:3]=1[CH2:21][C:22]([OH:24])=[O:23]참가 물질
4
실험 절차
To methyl (7-fluoro-2-(1-isoquinolinyl)-6-benzoxazolyl)acetate (155 mg, 0.46 mmol) were added THF (3 ml) and 0.5N NaOH (3.0 ml, 1.50 mmol). The resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was poured in ice-1N HCl to acidify the mixture therewith. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (7-fluoro-2-(1-isoquinolinyl)-6-benzoxazolyl)acetic acid (116 mg, 78%) as a brown solid.