Ethyl Acetoacetate → 2-(3,4-Dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

HRID 1372829

반응식

HRID 1372829 반응식
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([NH:10][NH2:11])[CH:6]=[CH:7][C:8]=1[CH3:9].[C:12](OCC)(=[O:17])[CH2:13][C:14]([CH3:16])=O.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:2][C:3]1[CH:4]=[C:5]([N:10]2[C:12](=[O:17])[CH:13]=[C:14]([CH3:16])[NH:11]2)[CH:6]=[CH:7][C:8]=1[CH3:9]

참가 물질

5

반응물 3

HCID 8868Ethyl AcetoacetateHCID 1737401-(3,4-Dimethylphenyl)hydrazine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 117358292-(3,4-Dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 3,4-dimethylphenylhydrazine hydrochloride (17.7 g; 0.1 mol.), ethyl acetoacetate (13.0 g; 0.1 mol.) and sodium acetate (8.2 g; 0.1 mol.) in glacial acetic acid; (250 mL) was stirred and heated under reflux for 24 h.

후처리

  1. temperatureheated
  2. temperatureunder reflux for 24 h.

출처 및 근거

ORD 기록
ord-23628097b02d4c7785b65863c79b4bb1
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160870B2

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