1,3-Benzenediacetonitrile → 2-[3-(2-Aminoethyl)phenyl]ethanamine
반응식
[C:1]1([CH2:10][C:11]#[N:12])[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]#[N:9])[CH:2]=1>CO.[Ni]>[C:3]1([CH2:7][CH2:8][NH2:9])[CH:4]=[CH:5][CH:6]=[C:1]([CH2:10][CH2:11][NH2:12])[CH:2]=1참가 물질
4
실험 절차
To a solution of 1,3-phenylenediacetonitrile (9.37 g, 60 mmol) in CH3OH (saturated with NH3, 150 mL) was added Raney-Ni (ca. 20 g, previously washed with CH3OH several times) and the mixture was hydrogenated at 45 psi on a Parr apparatus for 48 h. The reaction mixture was filtered through celite and the filtrate evaporated to give the crude product (9.45 g, 96%) as a light green oil: 1H NMR (CDCl3) δ 0.80–1.50 (br s, 4H), 2.70–2.76 (m, 4H), 2.94–2.99 (m, 4H), 7.01–7.07 (m, 3H), 7.18–7.26 (m, 1H). This was used in the next step without further purification.
후처리
- washpreviously washed with CH3OH several times) and the mixture
- filtrationThe reaction mixture was filtered through celite
- customthe filtrate evaporated
출처 및 근거
- ORD 기록
- ord-67fe9fa7508247699b225773adde4033
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07160872B2
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