Water → N-[2-(dimethylamino)ethyl]benzenesulfonamide

HRID 1373120노트

반응식

HRID 1373120 반응식
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[C:14]1([S:20](Cl)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O>ClCCl>[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH:5][S:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:22])=[O:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 66053N,N-Dimethylethylenediamine

생성물 1

HCID 2478570N-[2-(dimethylamino)ethyl]benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.8 g (30 mmol) of N,N-dimethylethylenediamine are placed in 100 ml of dichloromethane and 8.3 ml (60 mmol) of triethylamine. While cooling with ice a solution of 3.9 ml (30 mmol) of benzenesulphonic acid chloride in 100 ml of dichloromethane is added dropwise and the mixture is stirred overnight at ambient temperature. Water is added and the mixture is extracted with dichloromethane. The organic phase is dried and evaporated down.

후처리

  1. additionis added dropwise
  2. extractionthe mixture is extracted with dichloromethane
  3. customThe organic phase is dried
  4. customevaporated down

출처 및 근거

ORD 기록
ord-9340ad6b2c154970a0176672e48eda37
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160901B2

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