1-Acetyl-5-nitroindolin-2-one → 1-Acetyl-5-aminoindolin-2-one

HRID 1373134

반응식

HRID 1373134 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-])=O)=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:16])(=[O:3])[CH3:2].[H][H]>ClCCl.CO.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([NH2:13])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:16])(=[O:3])[CH3:2]

참가 물질

6

반응물 2

HCID 28393291-Acetyl-5-nitroindolin-2-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 120469981-Acetyl-5-aminoindolin-2-one

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

30.0 g (136 mmol) of 1-acetyl-5-nitro-2-indolinone are dissolved in a mixture of 650 ml of dichloromethane and 650 ml of methanol and after the addition of 5 g of 10% palladium on activated charcoal the mixture is hydrogenated for 45 minutes with hydrogen. Then the catalyst is filtered off and evaporated down.

후처리

  1. filtrationThen the catalyst is filtered off
  2. customevaporated down

출처 및 근거

ORD 기록
ord-20d1f7e55882484bb6b38a2f3b1021d2
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160901B2

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