Sodium Hydroxide → 3-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

HRID 1373138노트

반응식

HRID 1373138 반응식
[OH-].[Na+].C([N:6]1[C:14]2[C:9](=[CH:10][C:11]([N:15](C(=O)C)[S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[CH:12][CH:13]=2)[C:8](=[C:28]([O:35][CH2:36][CH3:37])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:7]1=[O:38])(=O)C>ClCCl.C(O)C>[CH2:36]([O:35][C:28](=[C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:17])=[O:18])[CH:10]=2)[NH:6][C:7]1=[O:38])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:37]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 695098291-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone

생성물 1

HCID 695105493-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

8 ml of 4 N sodium hydroxide solution are added to a solution of 4.0 g (8 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone (Example 1e) in a mixture of 20 ml of dichloromethane and 20 ml of ethanol and the resulting mixture is stirred for 20 minutes at ambient temperature. It is then evaporated down to about. 10 ml and 150 ml of water are added. The pH is adjusted to 8–9 with 1 N hydrochloric acid. The precipitate formed is suction filtered, washed with water, isopropanol and ether, then dried in vacuo.

후처리

  1. customIt is then evaporated down to about
  2. addition10 ml and 150 ml of water are added
  3. customThe precipitate formed
  4. filtrationfiltered
  5. washwashed with water, isopropanol and ether
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-ba86cf0e17ae4f448c9a4d64932f3d8f
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160901B2

반응 노트

불러오는 중…