Nitrobenzene → 1-(4-Nitrophenyl)-4-imidazolidinone

HRID 1373165노트

반응식

HRID 1373165 반응식
[NH:1]1[CH2:5][C:4](=[O:6])[NH:3][CH2:2]1.[N+:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([O-:9])=[O:8].C(N(C(C)C)CC)(C)C>CN(C=O)C>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([N:1]2[CH2:5][C:4](=[O:6])[NH:3][CH2:2]2)=[CH:12][CH:11]=1)([O-:9])=[O:8]

참가 물질

5

반응물 3

HCID 7416NitrobenzeneHCID 81531DiisopropylethylamineHCID 15020634-Imidazolidinone

생성물 1

HCID 210742741-(4-Nitrophenyl)-4-imidazolidinone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-imidazolidinone (9.5 g, 110.5 mmol), 4-nitrobenzene (1 eq) and diisopropyl ethylamine (28.6 mL, 165 mmol) in dry DMF (80 mL) was heated to 60° C. overnight under argon. The reaction mixture was allowed to cool to room temperature and ice pieces were added. The solid formed was filtered and washed with water. The solid was air dried to yield the nitro compound as yellow crystals.

후처리

  1. additionice pieces were added
  2. customThe solid formed
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-fbcb744e7e664f68805ac3377625e719
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160912B2

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