Methanol → HCID 21074219, 화합물

HRID 1373169노트

반응식

HRID 1373169 반응식
[CH3:1][C:2]1[CH:37]=[CH:36][CH:35]=[CH:34][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:22]=[C:23]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[CH3:33])[CH:24]=1)[C:9]([NH:11][C:12]1[N:17]=[CH:16][C:15]([C:18]([O:20]C)=[O:19])=[CH:14][CH:13]=1)=[O:10].CO.O.[OH-].[Na+]>C1COCC1>[CH3:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[CH2:26][O:25][C:23]1[CH:22]=[C:8]([CH:7]=[C:6]([O:5][CH2:4][C:3]2[CH:34]=[CH:35][CH:36]=[CH:37][C:2]=2[CH3:1])[CH:24]=1)[C:9]([NH:11][C:12]1[N:17]=[CH:16][C:15]([C:18]([OH:20])=[O:19])=[CH:14][CH:13]=1)=[O:10]

참가 물질

6

반응물 4

HCID 887MethanolHCID 962WaterHCID 14798Sodium HydroxideHCID 21074232HCID 21074232, 화합물

생성물 1

HCID 21074219HCID 21074219, 화합물수율 94.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 6-[(3,5-di-(2-methylbenzyloxy)benzoyl)amino]-3-pyridinecarboxylate (61 mgs) was stirred at ambient temperature in a mixture of THF (4 ml), methanol (1 ml) and water (1 ml) with 2M sodium hydroxide (0.3 ml, xs). After four hours the solvent was removed, under reduced pressure, water (5 ml) added and the pH adjusted to neutral. This gave a white precipitate which was filtered off, washed with water, dried to give the title compound (56 mgs, 94%). MS [MH]+ 483

후처리

  1. customAfter four hours the solvent was removed, under reduced pressure, water (5 ml)
  2. additionadded
  3. customThis gave a white precipitate which
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-41ded8f199b742bea0e18702015e46cf
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07160906B2

반응 노트

불러오는 중…