1-Methylpiperazine → 1-Methyl-4-(pyrrolidine-2-carbonyl)piperazine

반응식

[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=O.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:3]([CH:2]2[CH2:6][CH2:7][CH2:8][NH:1]2)=[O:5])[CH2:12][CH2:11]1

참가 물질

반응물 2

HCID 531671-Methylpiperazine

HCID 145742L-Proline

생성물 1

HCID 140848561-Methyl-4-(pyrrolidine-2-carbonyl)piperazine

실험 절차

Using analogous procedures to those described in Note [33] immediately above, 1-tert-butoxycarbonyl)-L-proline was reacted with 1-methylpiperazine to give (2S)-1-tert-butoxycarbonyl)-2-(4-methylpiperazin-1-ylcarbonyl)pyrrolidine which was deprotected and reacted with 2-bromoethanol. There was thus obtained the required starting material; NMR Spectrum: (CDCl3) 1.7–2.05 (m, 4H), 2.1–2.25 (m, 1H), 2.32 (s, 3H), 2.35–2.5 (m, 4H), 2.6–2.7 (m, 1H), 2.8–2.9 (m, 1H), 3.3–3.7 (m, 8H), 4.15 (br s, 1H); Mass Spectrum: M+H+ 242.

출처 및 근거

ORD 기록: ord-b57c9fa0806041a6bbdcc451131731db
출처 데이터셋: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07160891B2

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