Ethinylestradiol → Ethinyl Estradiol beta-cyclodextrin

HRID 1373675노트

반응식

HRID 1373675 반응식
[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH2:23]([OH:99])[C@H:24]1[O:29][C@@H:28]2[O:30][C@H:31]3[C@H:36]([OH:37])[C@@H:35]([OH:38])[C@@H:34]([O:39][C@H:40]4[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]5[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]6[C@H:63]([OH:64])[C@@H:62]([OH:65])[C@@H:61]([O:66][C@H:67]7[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:70]([O:75][C@H:76]8[C@H:82]([OH:83])[C@@H:81]([OH:84])[C@@H:79]([O:80][C@H:25]1[C@H:26]([OH:98])[C@H:27]2[OH:97])[O:78][C@@H:77]8[CH2:85][OH:86])[O:69][C@@H:68]7[CH2:87][OH:88])[O:60][C@@H:59]6[CH2:89][OH:90])[O:51][C@@H:50]5[CH2:91][OH:92])[O:42][C@@H:41]4[CH2:93][OH:94])[O:33][C@@H:32]3[CH2:95][OH:96]>CC(C)=O.O>[CH3:1][C@@:2]12[C@:18]([OH:21])([C:19]#[CH:20])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:22])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.[CH2:89]([OH:90])[C@H:59]1[O:60][C@@H:61]2[O:66][C@H:67]3[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:70]([O:75][C@H:76]4[C@H:82]([OH:83])[C@@H:81]([OH:84])[C@@H:79]([O:80][C@H:25]5[C@H:26]([OH:98])[C@@H:27]([OH:97])[C@@H:28]([O:30][C@H:31]6[C@H:36]([OH:37])[C@@H:35]([OH:38])[C@@H:34]([O:39][C@H:40]7[C@H:45]([OH:46])[C@@H:44]([OH:47])[C@@H:43]([O:48][C@H:49]8[C@H:54]([OH:55])[C@@H:53]([OH:56])[C@@H:52]([O:57][C@H:58]1[C@H:63]([OH:64])[C@H:62]2[OH:65])[O:51][C@@H:50]8[CH2:91][OH:92])[O:42][C@@H:41]7[CH2:93][OH:94])[O:33][C@@H:32]6[CH2:95][OH:96])[O:29][C@@H:24]5[CH2:23][OH:99])[O:78][C@@H:77]4[CH2:85][OH:86])[O:69][C@@H:68]3[CH2:87][OH:88]

참가 물질

5

반응물 2

HCID 5991Ethinylestradiol2회HCID 444041beta-Cyclodextrin2회

생성물 1

HCID 10214247Ethinyl Estradiol beta-cyclodextrin

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

Process 2 (P2): Ethinyl estradiol is dissolved in acetone. β-cyclodextrin is dissolved at 45 C in water. The ethinyl estradiol solution is added to the beta-cyclodextrin solution. The obtained suspension is stirred for some hours at temperatures below 25° C. Afterwards, the crystallization product is isolated and dried by methods described infra.

후처리

  1. customAfterwards, the crystallization product is isolated
  2. customdried by methods

출처 및 근거

ORD 기록
ord-3b956d393c104f7e92bd29215fe087a7
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07163931B2

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