반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[O:20])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8].[CH3:27][N:28]1[CH2:34][CH2:33][CH2:32][C:31](=O)[CH2:30][CH2:29]1.[BH3-]C#N.[Na+].C(O)(=O)C>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19]([CH:21]2[CH2:22][CH2:23][N:24]([CH:31]3[CH2:32][CH2:33][CH2:34][N:28]([CH3:27])[CH2:29][CH2:30]3)[CH2:25][CH2:26]2)=[O:20])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8]참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
The title compound is prepared from 5-chloro-2-(piperidin-4-ylcarbonylamino)-N-(5-chloropyridin-2-yl)-benzamide and 1-methyl-hexahydro-4H-azepin-4-one by reductive alkylation using NaCNBH3 and 5%-acetic acid in methanol, for example using a procedure similar to that of Example 25-F.
출처 및 근거
- ORD 기록
- ord-f3ea6a1a0d5a4e8ab9034749e7fa23fe
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07163938B2
연결된 노트
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