Ammonia → Carnosine

HRID 1374133노트

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HRID 1374133 반응식
[C:1]([CH2:3][C:4]([NH:6][C@@H:7]([CH2:11][C:12]1[N:13]=[CH:14][NH:15][CH:16]=1)[C:8]([OH:10])=[O:9])=[O:5])#[N:2].[Na].N>C(O)C.[Rh]>[CH:16]1[N:15]=[CH:14][NH:13][C:12]=1[CH2:11][C@H:7]([NH:6][C:4]([CH2:3][CH2:1][NH2:2])=[O:5])[C:8]([OH:10])=[O:9]

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 5360545SodiumHCID 178511198HCID 178511198, 화합물

생성물 1

HCID 439224Carnosine

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 702Ethanol용매

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온도
60 °C

실험 절차

0.3 g of rhodium/activated carbon (5% Rh) was added to a solution of 1.90 g (7.8 mmol) of (S)-2-(cyanoacetyl-amino)-3-(1H-imidazol-4-yl)propionic acid, sodium salt (prepared according to Example 1) in 50 ml of ethanol/conc. ammonia solution (V:V=4:1). The mixture was hydrogenated at 110° C. and 45 bar for 1 h. This was followed by filtering off the catalyst and adjusting the filtrate to a pH of 8.2 with formic acid. After concentrating the solution under reduced pressure, the residue was suspended in 200 ml of ethanol and heated at 60° C. for 30 min. The product was filtered off, washed successively with ethanol, ethyl acetate and diethyl ether and finally dried.

후처리

  1. customwas hydrogenated at 110° C.
  2. filtrationby filtering off the catalyst
  3. concentrationAfter concentrating the solution under reduced pressure
  4. filtrationThe product was filtered off
  5. washwashed successively with ethanol, ethyl acetate and diethyl ether
  6. customfinally dried

출처 및 근거

ORD 기록
ord-536ab27b869e4a9a8b5bc4c5184bc730
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07164028B2

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