Ethyl 2-(4-cyanophenyl)acetate → Ethyl 2-(4-(aminomethyl)phenyl)acetate

HRID 1374733노트

반응식

HRID 1374733 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1)#[N:2]>N.[Ni]>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1

참가 물질

4

반응물 1

HCID 279718Ethyl 2-(4-cyanophenyl)acetate

생성물 1

HCID 11535728Ethyl 2-(4-(aminomethyl)phenyl)acetate

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

0.5 g (2.6 mmol) of ethyl (4-cyanophenyl)acetate was dissolved in 70 ml of ethanolic ammonia solution and hydrogenated, at room temperature and under standard pressure, over Raney nickel. After 45 minutes, the mixture was filtered and evaporated. This resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate. MS (ES+): m/e=194.11

후처리

  1. filtrationthe mixture was filtered
  2. customevaporated
  3. customThis resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate

출처 및 근거

ORD 기록
ord-c29348e54dc74efa97f6cfaf37f94093
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166609B2

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