Pyrrolidine → HCID 11195876, 화합물

반응식

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][OH:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:14])[CH:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH3:14][C:4]1[CH:3]=[C:2]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[C:11]2[C:6](=[CH:7][C:8]([CH2:12][OH:13])=[CH:9][CH:10]=2)[N:5]=1

참가 물질

반응물 2

HCID 31268Pyrrolidine

HCID 11264243HCID 11264243, 화합물

생성물 1

HCID 11195876HCID 11195876, 화합물수율 90%

실험 절차

(4-Chloro-2-methyl-quinolin-7-yl)-methanol (750 mg, 3.61 mmol) was refluxed in pyrrolidine (6.42 g, 90.3 mmol) for 16 h. Most of the pyrrolidine was then removed under reduced pressure, the oily residue was taken up in toluene, evaporated, and the solid obtained triturated in ethyl acetate, filtered and dried to afford the title compound (785 mg, 90%). Light brown solid, ISP-MS: m/e==243.3 ([M+H]+).

후처리

customMost of the pyrrolidine was then removed under reduced pressure
customevaporated
customthe solid obtained
customtriturated in ethyl acetate
filtrationfiltered
customdried

출처 및 근거

ORD 기록: ord-54ef82eafdf743b38023efe9e89898f7
출처 데이터셋: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07166589B2

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