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Hydrazine hydrate (1:1) → 2-{1-[4-(2-Amino-ethyl)-2-p-tolyl-imidazol-1-yl]-2-methyl-propyl}-3-benzyl-5,6-dimethyl-3H-pyrimidin-4-one

HRID 1374874
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HRID 1374874 반응식
[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([CH3:16])[N:10]=[C:9]1[CH:17]([N:21]1[CH:25]=[C:24]([CH2:26][CH2:27][N:28]2C(=O)C3C(=CC=CC=3)C2=O)[N:23]=[C:22]1[C:39]1[CH:44]=[CH:43][C:42]([CH3:45])=[CH:41][CH:40]=1)[CH:18]([CH3:20])[CH3:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.NN>CCO>[NH2:28][CH2:27][CH2:26][C:24]1[N:23]=[C:22]([C:39]2[CH:40]=[CH:41][C:42]([CH3:45])=[CH:43][CH:44]=2)[N:21]([CH:17]([C:9]2[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:13](=[O:14])[C:12]([CH3:15])=[C:11]([CH3:16])[N:10]=2)[CH:18]([CH3:20])[CH3:19])[CH:25]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 210769262-(2-{1-[1-(1-Benzyl-4,5-dimethyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4-yl}-ethyl)-isoindole-1,3-dione

생성물 1

HCID 103899522-{1-[4-(2-Amino-ethyl)-2-p-tolyl-imidazol-1-yl]-2-methyl-propyl}-3-benzyl-5,6-dimethyl-3H-pyrimidin-4-one수율 72%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 2-(2-{1-[1-(1-Benzyl-4,5-dimethyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-2-p-tolyl-1H-imidazol-4yl}-ethyl)-isoindole-1,3-dione (0.371 g, 0.619 mmol) in EtOH (14 mL) was added hydrazine monohydrate (0.138 g, 2.48 mmol) and the reaction was stirred at room temperature for 72 h. The reaction was filtered and the filtrate was concentrated to dryness. The residue was purified by flash chromatography on silica gel (90:9:1 CH2Cl2:MeOH:NH4OH) to give the title compound as a white solid (0.209 g, 72%). MS(ES)+m/e 470 [M+H]+.

후처리

  1. filtrationThe reaction was filtered
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was purified by flash chromatography on silica gel (90:9:1 CH2Cl2:MeOH:NH4OH)

출처 및 근거

ORD 기록
ord-7dbc9bb18e9d4435a20c7e57d97fe714
출처 데이터셋
uspto-grants-2007_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07166595B2

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