Hydrochloric Acid → 3-Methoxy-4-methylbenzyl chloride
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[CH3:11])[CH2:6]O.[ClH:12].C(OC(C)C)(C)C>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[CH3:11])[CH2:6][Cl:12]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of 3-methoxy-4-methylbenzylalcohol (41.61 g), conc. hydrochloric acid (125 ml) and toluene (83 ml) was stirred at 90° C. for 1 hour. After cooling, ice-water (125 ml) and diisopropyl ether (80 ml) were added to the mixture, and the organic layer was separated, and the aqueous layer was extracted with diisopropyl ether (160 ml). The combined organic layer was washed with saturated sodium hydrogen carbonate solution and brine, dried over sodium sulfate, and evaporated in vacuo to give 3-methoxy-4-methylbenzyl chloride (46.35 g) as an oil.
후처리
- temperatureAfter cooling
- customthe organic layer was separated
- extractionthe aqueous layer was extracted with diisopropyl ether (160 ml)
- washThe combined organic layer was washed with saturated sodium hydrogen carbonate solution and brine
- dry with materialdried over sodium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-39ffb9a30e824374a9106730e09699e4
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07166598B2
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