Hydrochloric Acid → 4-Methyl-3-(phenylsulfonyl)-cyclohexan-1-one

HRID 1375121노트

반응식

HRID 1375121 반응식
[Na+].[C:2]1([S:8]([O-:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH:14]=[CH:13]1.Cl>O>[CH3:11][CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH:13]1[S:8]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:10])=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 2723840Benzenesulfinic acid, sodium saltHCID 109204694-Methyl-2-cyclohexenone

생성물 1

HCID 223949304-Methyl-3-(phenylsulfonyl)-cyclohexan-1-one수율 72%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Benzenesulfinic acid sodium salt (3.0 g) was added to a solution containing 1.52 g of 4-methyl-2-cyclohexene-1-one and 9 ml of water. 1N Hydrochloric acid (18 ml) was added dropwise to the resulting solution. After stirring at room temperature for 24 hours, the crystals so precipitated were filtered and washed with water, isopropanol and cold ethyl ether. After recrystallization from isopropanol, 4-methyl-3-(phenylsulfonyl)-cyclohexan-1-one (m.p.: 71–74) was obtained in the form of white crystals. Yield: 72%

후처리

  1. customthe crystals so precipitated
  2. filtrationwere filtered
  3. washwashed with water, isopropanol and cold ethyl ether
  4. customAfter recrystallization from isopropanol

출처 및 근거

ORD 기록
ord-ec3de838a3d64b668355fea4efc13a9a
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166642B1

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