4-Nitroaniline → N-(4-nitrophenyl)butanamide

HRID 1375286노트

반응식

HRID 1375286 반응식
[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([O-:3])=[O:2].CN1CCOCC1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>C(Cl)Cl>[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][C:18](=[O:22])[CH2:19][CH2:20][CH3:21])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 74754-NitroanilineHCID 79724-MethylmorpholineHCID 8855Butyryl chloride

생성물 1

HCID 346259N-(4-nitrophenyl)butanamide수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-nitro aniline (1.01 g, 7.23 mmol) in anhydrous CH2Cl2 (20 mL) was added NMM (0.95 mL, 8.68 mmol). To the reaction mixture was added dropwise butyryl chloride (1.00 mL, 8.68 mmol) at 0° C. After stirring for 0.5 h, the reaction was extracted with CH2Cl2 (20 mL), washed with H2O (30 mL), dried over Na2SO4, and evaporated in vacuo to give N-(4-Nitrophenyl)butyramide (1.50 g, 100%) as a white solid.

후처리

  1. extractionthe reaction was extracted with CH2Cl2 (20 mL)
  2. washwashed with H2O (30 mL)
  3. dry with materialdried over Na2SO4
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-b338941525c444359085adba3475575b
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166744B2

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