Dichloromethane → rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(4-hydroxy-2,2-dimethyl-butyl)-pyrrolidine-2-carboxylic acid (1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-amide
반응식
[CH:74]([N:75]([CH2:76][CH3:77])[CH:78]([CH3:79])[CH3:80])([CH3:81])[CH3:82].[Cl:83][CH2:84][Cl:85].[Cl:8][c:9]1[c:10]([F:40])[c:11]([CH:15]2[CH:16]([C:37](=[O:38])[OH:39])[NH:17][CH:18]([CH2:30][C:31]([CH2:32][CH2:33][OH:34])([CH3:35])[CH3:36])[C:19]2([C:20]#[N:21])[c:22]2[c:23]([F:29])[cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[cH:12][cH:13][cH:14]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[NH2:41][c:42]1[cH:43][c:44](=[O:49])[n:45]([CH3:48])[cH:46][cH:47]1.[P-:50]([F:51])([F:52])([F:53])([F:54])([F:55])[F:56].[n:57]1([O:58][C:59]([N:60]([CH3:61])[CH3:62])=[N+:63]([CH3:64])[CH3:65])[c:66]2[n:67][cH:68][cH:69][cH:70][c:71]2[n:72][n:73]1>>[Cl:8][c:9]1[c:10]([F:40])[c:11]([CH:15]2[CH:16]([C:37](=[O:38])[NH:41][c:42]3[cH:43][c:44](=[O:49])[n:45]([CH3:48])[cH:46][cH:47]3)[NH:17][CH:18]([CH2:30][C:31]([CH2:32][CH2:33][OH:34])([CH3:35])[CH3:36])[C:19]2([C:20]#[N:21])[c:22]2[c:23]([F:29])[cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[cH:12][cH:13][cH:14]1
