Water → [(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester

HRID 1375588노트

반응식

HRID 1375588 반응식
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[NH:4][CH3:5].C([O-])([O-])=O.[K+].[K+].Br[CH2:18][C:19]([O:21][CH3:22])=[O:20].O>CN1C(=O)CCC1>[CH3:22][O:21][C:19](=[O:20])[CH2:18][N:4]([C:3]1[CH:6]=[CH:7][C:8]([F:10])=[CH:9][C:2]=1[F:1])[CH3:5]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 27370232,4-difluoro-N-methylaniline

생성물 1

HCID 20627003[(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a mixture of the 2,4-Difluoro-N-methylaniline (Avacado Research Chemical, Heysham UK) (1.43 g, 10 mmole) in NMP, and K2CO3, was added methyl bromoacetate (0.945 ml, 10 mmole) and stirred at room temperature for 24 hours. The reaction mixture was added to water and extracted with ethyl acetate (3×50 ml), the organic extracts were washed 6× with water, dried (MgSO4) and evaporated to give the product as a oil.

후처리

  1. extractionextracted with ethyl acetate (3×50 ml)
  2. washthe organic extracts were washed 6× with water
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-f11cfb1394de4bf6b44418da7e9af3b6
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07169794B2

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