Sodium Hydroxide → 5-Methyl-3-phenylisoxazole-4-carboxylic acid

HRID 1375633

반응식

HRID 1375633 반응식
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO.O>[CH3:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]=1[C:3]([OH:4])=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 727920Methyl 5-methyl-3-phenyl-1,2-oxazole-4-carboxylate

생성물 1

HCID 143435-Methyl-3-phenylisoxazole-4-carboxylic acid수율 72%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester (0.853 g, 3.69 mmol) in methanol (12 mL) was added 2N NaOH (8 mL) the reaction solution was stirred at ambient temperature for 60 hr. The solution was dilute with water and extracted twice with ethyl acetate. The combined extract was washed with brine and dried over MgSO4 and concentrated. Recrystallization (hexanes/ethyl acetate) afforded a white solid (0.540 g, 72% yield).

후처리

  1. extractionextracted twice with ethyl acetate
  2. extractionThe combined extract
  3. washwas washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customRecrystallization (hexanes/ethyl acetate)

출처 및 근거

ORD 기록
ord-b96d7a5e95cf41579c754086b5928b63
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07169798B2

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