HCID 17986946, 화합물 → 4-(4-Fluorophenyl)butanenitrile

HRID 1376280노트

반응식

HRID 1376280 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([NH2:13])=O)=[CH:4][CH:3]=1>FC(F)(F)C(OC(=O)C(F)(F)F)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C:11]#[N:13])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 17986946HCID 17986946, 화합물

생성물 1

HCID 198754764-(4-Fluorophenyl)butanenitrile수율 100%

시약·촉매·용매 1

HCID 9845Trifluoroacetic anhydride용매

실험 절차

4(4-Fluorophenyl)-butyramide (Int. A4) (2.63 g) was dissolved in trifluoroacetic anhydride (10 ml) and stirred for 2 h. The solution was concentrated and then dissolved in dichloromethane and washed with 2N sodium hydroxide solution. The organics extracts were isolated, dried (MgSO4) and concentrated to yield the product (2.3 g, 100%) which contained ˜5% starting amide as an impurity. 1H-NMR (CDCl3) δ 1.96 (2H, app q), 2.31 (2H, t), 2.75 (2H, t), 6.98 (2H, m), 7.14 (2H, m). MS (APCI+)M+1=164, C10H10FN requires 163.

후처리

  1. concentrationThe solution was concentrated
  2. dissolutiondissolved in dichloromethane
  3. washwashed with 2N sodium hydroxide solution
  4. customThe organics extracts were isolated
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0b5fbeb9068747b3ad677d2c61cdfdea
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07169924B2

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