Hydrochloric Acid → Ethyl 2-ethylnorleucinate

HRID 1376407

반응식

HRID 1376407 반응식
C(=[N:8][C:9]([CH2:19][CH3:20])([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([O:12][CH2:13][CH3:14])=[O:11])C1C=CC=CC=1.Cl>>[CH2:13]([O:12][C:10](=[O:11])[C:9]([NH2:8])([CH2:19][CH3:20])[CH2:15][CH2:16][CH2:17][CH3:18])[CH3:14]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 10107458Ethyl 2-benzylideneamino-2-ethylhexanoate

생성물 1

HCID 42614420Ethyl 2-ethylnorleucinate수율 70%

반응 조건

온도
10 °C

실험 절차

A solution of the product from step (c) (1 mole) in 1N aqu. HCl (1.2 moles) was stirred for 10 minutes at room temperature, then washed with toluene. The pH of the remaining aqueous phase was adjusted to 7 using 12.5% w/v sodium hydroxide, then cooled to 10° C., further basified to pH 12 and extracted with toluene. The extracts were combined, washed with brine, dried and evaporated in vacuo. The residue was distilled to give the desired product as an oil (70-80% yield).

후처리

  1. washwashed with toluene
  2. extractionextracted with toluene
  3. washwashed with brine
  4. customdried
  5. customevaporated in vacuo
  6. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-39f8b6c166914f39ba69080cb69c09ee
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05663165

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