1-Diphenylmethylamino-2-phenylethylphosphonous acid → 1-Amino-2-phenylethylphosponous acid

HRID 1376425노트

반응식

HRID 1376425 반응식
C1(C([NH:14][CH:15]([P:23]([OH:25])[OH:24])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)C2C=CC=CC=2)C=CC=CC=1>Br>[NH2:14][CH:15]([P:23]([OH:25])[OH:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

3

반응물 1

HCID 229165271-Diphenylmethylamino-2-phenylethylphosphonous acid

생성물 1

HCID 229165291-Amino-2-phenylethylphosponous acid

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

실험 절차

9.9 g (0.028 mol) of 1-diphenylmethylamino-2-phenylethylphosphonous acid are heated, at 100°-105° C. for 2 h, in 50 ml of 40% hydrobromic acid. The reaction solution is then evaporated to dryness i.V. and the residue is taken up in 50 ml of water. The aqueous solution is washed several times with diethyl ether and evaporated to dryness. The residue is dissolved in 60 ml of ethanol and propylene oxide is added to the solution until the product precipitates out. After the mixture has been left to stand overnight, the precipitate is filtered off with suction, washed with ethanol/diethyl ether and dried.

후처리

  1. customThe reaction solution is then evaporated to dryness i.V
  2. washThe aqueous solution is washed several times with diethyl ether
  3. customevaporated to dryness
  4. dissolutionThe residue is dissolved in 60 ml of ethanol
  5. additionpropylene oxide is added to the solution until the product
  6. customprecipitates out
  7. waitAfter the mixture has been left
  8. filtrationthe precipitate is filtered off with suction
  9. washwashed with ethanol/diethyl ether
  10. customdried

출처 및 근거

ORD 기록
ord-9aa50f4c9c224ff5aefb63bcf3db20c3
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05663139

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