Sodium Hydroxide → 5-(N-Methylamino)methylimidazo[5,1-b]thiazole

HRID 1376601노트

반응식

HRID 1376601 반응식
[CH3:1][N:2]([CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1)C(=O)C(F)(F)F.[OH-].[Na+]>CO>[CH3:1][NH:2][CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 229167005-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole

생성물 1

HCID 212624035-(N-Methylamino)methylimidazo[5,1-b]thiazole수율 109.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 394 mg (1.49 mmol) of the above-obtained 5-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole in 3 ml of methanol was added 3 ml of a 10% aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 1 hour. The methanol was distilled off under reduced pressure. The resultant was extracted three times with chloroform. The organic layer was dried over anhydrous potassium carbonate, and concentrated under reduced pressure to give 272 mg of the title compound as an oil.

후처리

  1. distillationThe methanol was distilled off under reduced pressure
  2. extractionThe resultant was extracted three times with chloroform
  3. dry with materialThe organic layer was dried over anhydrous potassium carbonate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b23bb46eae8742218a636a1c5b8af5e5
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05663162

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