Hydrochloric Acid → HCID 70207318, 화합물

HRID 1378389노트

반응식

HRID 1378389 반응식
C(OC([NH:8][CH2:9][C@H:10]1[C@H:14]([C:15]([F:18])([F:17])[F:16])[CH2:13][NH:12][CH2:11]1)=O)(C)(C)C.FC(F)(F)C(O)=O.Cl>ClCCl>[NH2:8][CH2:9][C@H:10]1[C@H:14]([C:15]([F:18])([F:16])[F:17])[CH2:13][NH:12][CH2:11]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 57429455Carbamic acid, [[(3R,4R)-4-(trifluoromethyl)-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester, rel-

생성물 1

HCID 70207318HCID 70207318, 화합물수율 88.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

In 1 ml of dichloromethane, is dissolved 202 mg (0.754 mmol) of trans-3-(tert-butoxycarbonylaminomethyl)-4-trifluoromethylpyrrolidine. To the above solution, is added 1 ml of trifluoroacetic acid on cooling with ice, and the mixture is stirred at 0° C. for 1 hour. To the reaction mixture, is added 0.19 ml of conc-hydrochloride, and the mixture was concentrated under reduced pressure to give 161 mg of the objective substance as a slightly yellow powder (yield 88.6%).

후처리

  1. temperatureon cooling with ice
  2. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-309054bc17104c7da262620b31d23a7b
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668147

반응 노트

불러오는 중…