1,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-one → HCID 2801509, 화합물

HRID 1378396노트

반응식

HRID 1378396 반응식
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([CH:7]=[CH:8][C:9]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[O:10])=[CH:5][CH:4]=1.[H][H]>C1COCC1.CO.[Pt](=O)=O>[CH3:20][O:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][CH2:11][C:9](=[O:10])[CH2:8][CH2:7][C:6]2[CH:21]=[CH:22][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:18][CH:17]=1

참가 물질

5

반응물 2

HCID 1012201,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 2801509HCID 2801509, 화합물수율 59.5%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

To a solution of commercially available di(4-methoxybenzylidene) acetone (3.5 g, 12 mmol) in THF-MeOH (1:1,100 mL) was added platinum (IV) oxide (90 mg) and the resulting mixture was stirred at room temperature under 4 atmospheres of hydrogen for 19 hours. The catalyst was filtered and washed with THF, and the filtrate was concentrated in vacuo. The residue was purified by chromatography on silica gel (hexane-ethyl acetate 3:1) to provide 1,5-bis(4-methoxyphenyl)-3-pentanone (2.13 g) and the reduced side product 1,5-bis(4-methoxyphenyl)-3-pentanol (1.0 g).

후처리

  1. filtrationThe catalyst was filtered
  2. washwashed with THF
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe residue was purified by chromatography on silica gel (hexane-ethyl acetate 3:1)

출처 및 근거

ORD 기록
ord-05fb986b373f45938dbf6fad166d9702
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668146

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