Dimethylformamide → 4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one

HRID 13794

반응식

HRID 13794 반응식
Cl[CH2:2][C:3]1[O:4][C:5](=[O:9])[O:6][C:7]=1[CH3:8].[Br-:10].[Na+].CN(C)C=O>CC(C)=O>[Br:10][CH2:2][C:3]1[O:4][C:5](=[O:9])[O:6][C:7]=1[CH3:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 253881Sodium BromideHCID 98555184-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

생성물 1

HCID 107741414-(Bromomethyl)-5-methyl-1,3-dioxol-2-one

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 403 mg of 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one and 525 mg of sodium bromide was added 0.8 ml of anhydrous N,N-dimethylformamide, followed by at room temperature for 1.5 hours. To the reaction solution was added 1.2 ml anhydrous acetone, the mixture was further stirred at room temperature for 1 hour, and then insolubles were removed by filtration. Insolubles were washed three times with 0.8 ml of anhydrous acetone, and the resulting pale yellow solution was used in the next reaction.

후처리

  1. custominsolubles were removed by filtration
  2. washInsolubles were washed three times with 0.8 ml of anhydrous acetone
  3. customthe resulting pale yellow solution was used in the next reaction

출처 및 근거

ORD 기록
ord-7673f946ac5a4594919a73190681f2f3
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728131B2

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