Benzoyl chloride → N4-Benzoyl-2'-deoxycytidine

HRID 1379763노트

반응식

O.[C@@H:2]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:3]1.N#N.[C:20]([C@@:25]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H:29]([CH2:30][OH:31])[C@@H:27](O)[CH2:26]1)(=O)[CH:21](C)C.C(Cl)(=O)C1C=CC=CC=1>>[C:30]([NH:15][C:14]1[CH:16]=[CH:17][N:10]([C@@H:2]2[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:3]2)[C:11](=[O:12])[N:13]=1)(=[O:31])[C:29]1[CH:21]=[CH:20][CH:25]=[CH:26][CH:27]=1

참가 물질

반응물 3

HCID 7412Benzoyl chloride

HCID 27243552'-Deoxycytidine hydrate

HCID 136395926HCID 136395926, 화합물

생성물 1

HCID 9797617N4-Benzoyl-2'-deoxycytidine

실험 절차

This compound was prepared from 2'-deoxycytidine monohydrate by the same procedure used for the preparation of N2 -isobutyryl-2'-deoxyguanosine except that 9.0 mL (77.5 mmol, 5.17 equiv.) of benzoyl chloride was used instead of isobutyric anhydride.

출처 및 근거

ORD 기록: ord-8e357cf8a19541ed8e76e29d7009f2a2
출처 데이터셋: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05672697

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