Dimethyl Sulfoxide → 16-Bromohexadec-5-ene

HRID 1380167

반응식

HRID 1380167 반응식
[CH:1]([Br:17])=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].CS(C)=O.C([O-])(O)=O.[Na+]>>[CH2:1]([Br:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

4

반응물 3

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 54030172Hexadecenyl bromide

생성물 1

HCID 5444018716-Bromohexadec-5-ene

반응 조건

온도
60 °C

실험 절차

Hexadecenyl bromide (360 g; 1.2 mol) and 1800 mL (2660 g; 34 mol) of DMSO were mixed and heated to 60° C. for 30 minutes. Then, NaHCO3 and a co-solvent were added, pressure reduced and temperature raised for the period of time specified in Table I. Reaction mixture was then cooled and concentrated on a rotary evaporator. GLC analysis was then carried out to determine aldehyde/alcohol ratios in the reaction product. Results from reactions employing several different co-solvents are summarized in Table I as runs 5-9.

후처리

  1. temperaturetemperature raised for the period of time
  2. customReaction mixture
  3. temperaturewas then cooled
  4. concentrationconcentrated on a rotary evaporator
  5. customResults from reactions

출처 및 근거

ORD 기록
ord-96d7a0d1a2dc4bbdacb0e62356c65943
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579977

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