홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Tetrahydrofuran → N-[6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-3-(1-hydroxyethyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

HRID 13804
노트
인쇄 미리보기

반응식

HRID 13804 반응식
[C:1]([C:4]1[C:5](=[O:34])[N:6]([CH3:33])[C:7]2[C:12]([C:13]=1[NH:14][C:15](=[O:17])[CH3:16])=[CH:11][C:10]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)=[C:9]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[Cl:32])[N:8]=2)(=[O:3])[CH3:2].C1COCC1.[BH4-].[Na+]>CO>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([C:10]2[CH:11]=[C:12]3[C:7](=[N:8][C:9]=2[C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=2[Cl:32])[N:6]([CH3:33])[C:5](=[O:34])[C:4]([CH:1]([OH:3])[CH3:2])=[C:13]3[NH:14][C:15](=[O:17])[CH3:16])=[CH:19][CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 11386747Naphthyridinone

생성물 1

HCID 11283741N-[6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-3-(1-hydroxyethyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The product of Example 1 (65 mg), THF (3 mL), MeOH (0.33 mL) and NaBH4 (9.6 mg) were combined at room temperature. After 7 minutes the reaction was concentrated and then dissolved in EtOAc before washing with water and drying (Na2SO4). The concentrated residue was purified by preparative TLC (silica gel) eluted with EtOAc affording the title compound. HPLC/MS: 515.9 (M+1), 517.9 (M+3); Rt=3.68 min.

후처리

  1. customwere combined at room temperature
  2. concentrationAfter 7 minutes the reaction was concentrated
  3. dissolutiondissolved in EtOAc
  4. washbefore washing with water
  5. dry with materialdrying (Na2SO4)
  6. customThe concentrated residue was purified by preparative TLC (silica gel)
  7. washeluted with EtOAc affording the title compound

출처 및 근거

ORD 기록
ord-b5b31bbe1b2e446d94d4b4c91c35140c
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07728141B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트