Urea → 5-(Heptafluoropropyl)dihydropyrimidine-2,4(1H,3H)-dione

HRID 1380434노트

반응식

HRID 1380434 반응식
[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[C:3]([F:10])([F:9])[C:4](=[CH2:8])[C:5](O)=[O:6].[NH2:16][C:17]([NH2:19])=[O:18].C(OC(=O)C)(=O)C>C(O)C>[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[C:3]([F:10])([F:9])[CH:4]1[CH2:8][NH:19][C:17](=[O:18])[NH:16][C:5]1=[O:6]

참가 물질

5

반응물 3

HCID 1176UreaHCID 7918Acetic AnhydrideHCID 21277491HCID 21277491, 화합물

생성물 1

HCID 134576425-(Heptafluoropropyl)dihydropyrimidine-2,4(1H,3H)-dione수율 64%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

A mixture of α-heptafluoropropylacrylic acid (240 mg; 1.0 mmole), urea (64 mg; 1.1 mmoles) and acetic anhydride (0.6 ml) was heated at 100° C. with stirring for 40 minutes. Then, ethanol (3 ml) was added to the reaction mixture to give 180 mg (yield: 64%) of 5-heptafluoropropyldihydrouracil as colorless crystals. m.p.: 223°-224 (decomp.).

출처 및 근거

ORD 기록
ord-9eb026844fda4258b6f30257cbd6f2de
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04581452

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