Ammonium Chloride → HCID 23325186, 화합물

HRID 1380487노트

반응식

HRID 1380487 반응식
[Na].C[Si](C)(C)[C:4]#[C:5][CH:6]([N:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10].[Cl-].[NH4+]>CO>[CH:14](=[N:13][CH:6]([C:5]#[CH:4])[CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 13780253Methyl 4-[(phenylmethylene)amino]-6-(trimethylsilyl)-5-hexynoate

생성물 1

HCID 23325186HCID 23325186, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

0.0764 g of sodium was dissolved in 5 ml of methanol. The solution was added at room temperature to a solution of 1.0 g of 3A in 2 ml of dry methanol. The mixture was stirred at room temperature for 4 hours, then 0.1765 g of ammonium chloride was added and the mixture was stirred for 15 minutes. Then the methanol was evaporated, the residue was triturated with ether and the solid phase was filtered off. The solvent was evaporated from the filtrate and the residue was distilled to give 4, b.p.: 170° C. (0.07 Torr).

후처리

  1. stirringthe mixture was stirred for 15 minutes
  2. customThen the methanol was evaporated
  3. customthe residue was triturated with ether
  4. filtrationthe solid phase was filtered off
  5. customThe solvent was evaporated from the filtrate
  6. distillationthe residue was distilled
  7. customto give 4, b.p.: 170° C. (0.07 Torr)

출처 및 근거

ORD 기록
ord-694019a6c8ad45ccb28cbe5e11874e9f
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582529

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