Methyl iodide → 4H-1,2,4-Triazole, 3-methyl-5-(methylthio)-4-phenyl-

HRID 1380502노트

반응식

HRID 1380502 반응식
[SH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:5]([CH3:13])=[N:4][N:3]=1.[CH3:14][O-].[Na+].CI>CO>[CH3:13][C:5]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:2]([S:1][CH3:14])=[N:3][N:4]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 178434153HCID 178434153, 화합물

생성물 1

HCID 11432464H-1,2,4-Triazole, 3-methyl-5-(methylthio)-4-phenyl-

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Mercapto-5-methyl-4-phenyl-1,2,4-triazole (19.1 g) was suspended in 200 ml of methanol, and 20 g of 28% sodium methylate was added thereto. After 10 minutes, 15 g of methyl iodide was added dropwise. They were reacted for 2 hours and then the methanol was distilled away. Upon extraction of the residue with ethyl acetate, 5-methyl-3-methylthio-4-phenyl-1,2,4-triazole was obtained.

후처리

  1. customThey were reacted for 2 hours
  2. distillationthe methanol was distilled away
  3. extractionUpon extraction of the residue with ethyl acetate

출처 및 근거

ORD 기록
ord-970414d2952748089b2f3c030f78eff8
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582775

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