4,6-Nonanedione → 4-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester

HRID 1380521

반응식

HRID 1380521 반응식
[NH2:1][C:2]1[NH:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:9][CH2:8]2)=[N:5][N:6]=1.[CH3:18][CH2:19][CH2:20][C:21](=O)[CH2:22][C:23](=O)[CH2:24][CH2:25][CH3:26]>C(O)(=O)C>[CH2:20]([C:21]1[CH:22]=[C:23]([CH2:24][CH2:25][CH3:26])[N:6]2[N:5]=[C:4]([N:7]3[CH2:8][CH2:9][N:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:11][CH2:12]3)[N:3]=[C:2]2[N:1]=1)[CH2:19][CH3:18]

참가 물질

4

반응물 2

HCID 264544,6-NonanedioneHCID 1784733584-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester

생성물 1

HCID 136860144-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester수율 93.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 4.48 g (0.02 moles) of 4-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester, 3.12 g (0.02 moles) of 4,6-nonanedione and 50 ml of glacial acetic acid was refluxed for 12 hours. The resulting solution was evaporated to dryness in vacuo. The residue was partitioned and treated as described in Example 12 and gave 6.77 g of the desired product as colorless crystals, mp 130°-132° C.

후처리

  1. temperaturewas refluxed for 12 hours
  2. customThe resulting solution was evaporated to dryness in vacuo
  3. customThe residue was partitioned
  4. additiontreated

출처 및 근거

ORD 기록
ord-be58f9a26e5748d680e52bd587380267
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582833

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