HCID 13603776, 화합물 → HCID 13519806, 화합물
반응식
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[C:5]([CH2:12][CH2:13][C:14]([OH:16])=O)[CH:6]=[CH:7][CH:8]=2)[NH:3]1>C(OC(=O)C)(=O)C>[CH2:10]1[C:9]2=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]2[N:3]([C:14](=[O:16])[CH2:13][CH2:12]3)[C:2](=[O:1])[CH2:11]1참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
1,2,3,4-Tetrahydro-2-oxo-8-quinolinepropanoic acid (2.1 g, 0.0096 mole) is dissolved in acetic anhydride (10 ml) and the solution is heated to 100° C. for one hour. Excess acetic anhydride is removed at reduced pressure and the residual anhydride is removed by addition of toluene and repeated concentration. The solid is recrystallized from ethyl acetate to yield pure 1,2,6,7-tetrahydro-3H,5H-benzo[ij]-quinolizine-3,5-dione, mp 136°-140° C.
후처리
- customExcess acetic anhydride is removed at reduced pressure
- customthe residual anhydride is removed by addition of toluene
- concentrationconcentration
- customThe solid is recrystallized from ethyl acetate
출처 및 근거
- ORD 기록
- ord-dea381f0966749ccab4d86e2a94546a0
- 출처 데이터셋
- uspto-grants-1986_04
- 특허 번호
- US04582909
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