Hydrochloric Acid → HCID 20184547, 화합물

HRID 1380721노트

반응식

HRID 1380721 반응식
[CH3:1][N:2]([CH3:21])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2.[ClH:22].[H][H]>CO.[Pd]>[ClH:22].[ClH:22].[CH3:1][N:2]([CH3:21])[C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 132845112-(1H-Imidazo[4,5-b]pyridin-2-yl)-N,N-dimethyl-5-nitroanilineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20184547HCID 20184547, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

An amount of 2.83 gm of 2-(2'-dimethylamino-4'-nitrophenyl)-imidazo[4,5-b]pyridine was hydrogenated in a mixture of 100 ml of methanol, 10 ml of concentrated methanolic hydrochloric acid, and 1 gm of palladium/charcoal for 4.5 hours at ambient temperature with hydrogen gas at 5 bar. The catalyst was then removed by filtration, the filtrate was concentrated by evaporation, and the residue was triturated with acetone to form crystals, filtered, and then washed with a mixture of ether and acetone.

후처리

  1. customThe catalyst was then removed by filtration
  2. concentrationthe filtrate was concentrated by evaporation
  3. customthe residue was triturated with acetone
  4. customto form crystals
  5. filtrationfiltered
  6. washwashed with a mixture of ether and acetone

출처 및 근거

ORD 기록
ord-0d149e7db7d84c7b8b89c3fcf3eed068
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582837

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